red barn

a mthfr

a few years back, i had a genetic test done. one thing it showed i had the mthfr mutation. that’s not completely surprising since about one in three people have that mutation. if you add some appropriate vowels and consonants in appropriate places, you’ll see what i think of this mutation.

what’s it mean for people with the mthfr mutation? the main thing about this gene is that it indicates how the body breaks down folic acid. it breaks it down to methylfoldate. methylfolare is required for such neurotransmitters as serotonin, dopamine, and norepinehrine.

i don’t know if you know about these neurotransmitters. they are important in communication between brain cells. shortages with these neurotransmitters are often associated with depression because the brain cells have a reduce ability to communicate. the relationship of neurotransmitters are completely understood. otherwise you wouldn’t be depressed reading my blog on depression.

what can be done if you had the mutant gene? throwing a bunch at folic acid won’t help. because of the mutation, the body can process the folic acid into a usable form. if you have a one gallon tank, pouring a thousand gallons into it doesn’t fill the tank with more than one gallon.

that still begs the question, is there anything that can be done. the answer is yes, of some people. take vitamin b-9 or methylfolate. methylfolate, being a broken down version of folic acid, it come preprocessed and can go straight to the brain and contribute building blocks for the neurotransmitters.

l-methylfolate, as know in in-takable form, is sometimes is called a booster. not only does the methylfolate improve the production of neurotransmitters, if can also improve the effectiveness of anti-depressant.

one of the nice thing about l-merhyalfolate is a pretty good success rate and low reported side-effects. some reports even say no side-effects but some lists show minor and relatively rare side effects.

many people with the mthfr mutation benefit from l-methylfolate. the prescription version is delphin. it costs $200/month. methylfolate is available from for about $25/month. the methylpro version has the exact same “active” ingredient. methylpro gets around the prescription drug regulation by adding some vitamin b-6. that makes it a supplement!

most people with the mthfr mutation usually benefit from the higher doses. methylpro has some of the best prices available for the higher doses. you can find seemingly lower prices for lower doses, but when the lower dosage is taken into account, the price savings disappears.

haven’t had genetic testing done? check with your doctor. some doctors aren’t on board with it as of yet.

without insurance, it can cost in the mid four digit range. don’t freak. my doctor used a lab where if insurance didn’t pay for the test, patients would be charged a very low cost or even given the test for free, as it was in my case. hopefully, your doctor also know of such labs. from what understand that practice is pretty common.

you may want to find out if you have the mthfr mutation. if you don’t, consider youself lucky. if you do, know that there may be help on the way. the mthfr mutation is only a contributing factor. l-metrofolate may help to give you a leg up.

note: i am not doctor. this blog contains experienced and researched information. in no way is it intended to be prescribed or a recommended method of treatment. that can only be down under the watchful eye of your medical provider. please consult your doctor before starting any new method of treatment.

4 thoughts on “a mthfr

  1. swanyriver

    Hi sweetie I am praying and hoping you are getting some relief from your medicine.💜 I have not been seeing your posts from my regular feed, but just found them in my reader. I miss you and am thinking of you 3rd son! Thank you for this great informative post, you are helping others by sharing all you know! Hugs!💜💜💜

  2. Pingback: a turn | facing off with the big d

  3. jsinco

    My daughter was tested since she is pregnant and was told she has the gene from both her parents. So, if that is the answer, do I still need to be tested on my ?

    1. bipolarsojourner Post author

      short answer: no

      Long answer: (I’m good it long answers)each gene has two alleles. they are either dominant or recessive. so that leaves four states, de, dr, rd, rr. for the sake of genes order doesn’t matter so the two middle states combine to one.

      so there isn’t a gene explosion, the mother and father contribute half of their genes (that’s a cool process call rna that would double the length of this). your daughter has two recessive genes so that means you contributed a recessive gene. it is still unknown whether your other allele is recessive or dominant. so, all we can say is that you are either dr or rr.

      I found a video on the Internet by a doctor, can’t remember where, and the doctor said that one recessive gene decreases the bodies capability to process folic acid by 40% and the double recessive reduces capability by 70%.

      so, your ability to process folic acidic is reduced by 40% if not 70%. one byproducts of the folic acid process is methyl folate. that is a building block for at least 3 neurotransmitters. those neurotransmitters are key to brain cells communicating with each other. there is at least a pretty strong causal relationship between the lack of neurotransmitters and depression.

      determining therapy strictly by genes is not the be all to end. i am single recessive on the mthfr gene. that implies methyl folate would help me. my doc put me on 15mg. that put into rapid cycle between a deeper depression and moderate depression. my guess is i over folated causing too many neurotransmitters causing cycling. my doc suggested if we try again, that I back of to 1 mg.


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